genetron health
Glioma is the most common type of primary brain tumor. It has high recurrence and mortality rates. Accurate classification plays a guiding role in subsequent treatments. In 2016, the WHO Classification of Tumors of the Central Nervous System first introduced classification of CNS tumors integrated with histological phenotypes and genotyping, setting up new roles for molecular classification in clinical diagnosis and treatment. Clinical treatment of glioma involves surgery in combination with radiotherapy and chemotherapy. A variety of targeted drugs are being tested in clinical trials. High-throughput genetic tests can detect multiple gene variants at once, providing clinical evidence for the use of targeted drugs.
genetron health
genetron health
Cancer is a complex genetic disease. The vast majority of tumors result from joint effects of genetic and environmental factors. The formation and development of tumors is the result of accumulated changes of cytogenetics induced by carcinogens.
Somatic mutations refer to mutations in tumor cells and occurs in non-germ line cells. Somatic mutations will not be passed on to future generations. Germline mutations are inherited from the parents, occur during embryonic formation, and exist in both normal tissues and tumor tissues.
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